FORMULATION AND OPTIMIZATION OF TERBINAFINE HCl SOLID LIPID NANOPARTICLES FOR TOPICAL ANTIFUNGAL ACTIVITY
By: Abobakr, Fatma E
.
Contributor(s): Sahar, M. Fayez.
Publisher: M P Innovare Academic Sciences Pvt Ltd 2019Edition: Vol.11(12).Description: 16-25p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
International journal of pharmacy and pharmaceutical scienceSummary: Objective:
Soli
d lipid nanoparticles (SLNs) are
at the forefront
of the rapidly developing field of nanotechnology with several potential applications
in drug delivery and res
earch.
The aim of this study was
to
develop and characterize SLNs formulae of Terbinafine HCl
(TFH) for
topical drug
delivery
application
s.
Method
s:
SLNs were prepared using the solvent
injection technique. Glyceryl M
onostearate (GMS) served as the lipid base.
Three
stabilizer
s;
Tween 80, C
remophor
RH40
, and
Poloxame
r 188
, were used. The effect of stabilizer
type and
concentration
, as well
as
the li
pid concentration
, were
studied
, factorial design of
3
2
*2
1
was applied.
The prepared SLNs were characterized
regarding
their
particle size, zeta potential, polydispersity
index
(PDI)
, entrapment eff
iciency
percent
(EE %)
, and physicochemical
stability.
The
selected formulae were subjected to further investigations
such as morphological studies,
in vitro
release studies
, and Infrared (IR) spectroscopy.
The
y were compared with
the marketed
cream
Lamifen
®
in
term of their antifungal activity
against
Candida alb
icans
.
Result
s:
Lipid concentration
, together with the type and concentration of stabilizer
, appeared to be
the main cornerstones
which
affect the
formation of SLNs. Smaller particle size was observed
when
increasing the stabilizer concentration
and decrea
sing the lipid concentration. Higher
EE% was observed
when
increasing both the stabilizer and the lipid concentration
s. Formulae (F6, F12 andF19) were selected as the most suitable
SLNs
with
optimum particle size of 480.2
±18.89, 458.6
±12.45
and
246.7
±10.5
nm
, respectively as well as the highest EE% of 87.13
±0.19, 93.69
±0.7
and
95.06
±0.25
, respectivel
y.
In vitro
microbiological
screening of
their
antifungal activity showed significantly larger
zone
s of inhibition
of
diameters 25.9
±0.25,
25
±0.35
and
24.67
±0.3
6 mm
, respectively
in comparison with the marketed
Lamifen®
cream
which showed a zone of
11.2
±0.44 mm diameter
.
Conclusio
n:
Applying
SLNs
containing TFH
as topic
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|
Articles Abstract Database
|
School of Pharmacy Archieval Section | Not for loan | 2020966 |
Objective:
Soli
d lipid nanoparticles (SLNs) are
at the forefront
of the rapidly developing field of nanotechnology with several potential applications
in drug delivery and res
earch.
The aim of this study was
to
develop and characterize SLNs formulae of Terbinafine HCl
(TFH) for
topical drug
delivery
application
s.
Method
s:
SLNs were prepared using the solvent
injection technique. Glyceryl M
onostearate (GMS) served as the lipid base.
Three
stabilizer
s;
Tween 80, C
remophor
RH40
, and
Poloxame
r 188
, were used. The effect of stabilizer
type and
concentration
, as well
as
the li
pid concentration
, were
studied
, factorial design of
3
2
*2
1
was applied.
The prepared SLNs were characterized
regarding
their
particle size, zeta potential, polydispersity
index
(PDI)
, entrapment eff
iciency
percent
(EE %)
, and physicochemical
stability.
The
selected formulae were subjected to further investigations
such as morphological studies,
in vitro
release studies
, and Infrared (IR) spectroscopy.
The
y were compared with
the marketed
cream
Lamifen
®
in
term of their antifungal activity
against
Candida alb
icans
.
Result
s:
Lipid concentration
, together with the type and concentration of stabilizer
, appeared to be
the main cornerstones
which
affect the
formation of SLNs. Smaller particle size was observed
when
increasing the stabilizer concentration
and decrea
sing the lipid concentration. Higher
EE% was observed
when
increasing both the stabilizer and the lipid concentration
s. Formulae (F6, F12 andF19) were selected as the most suitable
SLNs
with
optimum particle size of 480.2
±18.89, 458.6
±12.45
and
246.7
±10.5
nm
, respectively as well as the highest EE% of 87.13
±0.19, 93.69
±0.7
and
95.06
±0.25
, respectivel
y.
In vitro
microbiological
screening of
their
antifungal activity showed significantly larger
zone
s of inhibition
of
diameters 25.9
±0.25,
25
±0.35
and
24.67
±0.3
6 mm
, respectively
in comparison with the marketed
Lamifen®
cream
which showed a zone of
11.2
±0.44 mm diameter
.
Conclusio
n:
Applying
SLNs
containing TFH
as topic
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